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these bioactive molecules act on multiple targetsincluding EMT-related transcription factors and key signaling cascadesto effectively block epithelial-mesenchymal conversion, suppress myofibroblast activation and regulate aberrant extracellular-matrix (ECM) remodeling, thereby markedly curbing EMT progression and fibrotic disease ( Triptolide (TP), an active diterpenoid extracted from Tripterygium wilfordii Hook F, possesses anti-inflammatory, antiproliferative and immunomodulatory properties, and has been widely investigated in experimental idiopathic pulmonary fibrosis (IPF) models in recent years ( Total saponins of Astragalus membranaceus (ASTs) are the principal active constituents isolated from Astragalus membranaceus

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PS is a complex formulation that consists primarily of 90% phospholipids and 10% proteins (83)

FIGURE 8 As AC6 shows remarkable physiological benefits for the heart, while its content and function are diminished in the failing heart (Ostrom et al., 2022), there has been increased interest in the efficacy and safety of adenoviral delivery of AC6 in patients with heart failure (Hammond et al., 2016) (AC6 Clinical Trials)

As early as 4 hours after APAP poisoning, patients exhibit abnormal plasma GST levels that remain elevated 12 hours after ingestion of the drug [48]