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In AD, EWAS studies utilising bulk brain tissue have identified multiple genes with DNA methylation changes associated with the disease and its pathological burden [47, 61, 98, 111], and meta-analyses have identified significant changes across multiple brain regions [91, 96, 99, 118]
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To strengthen the physiological relevance of our findings, we conducted additional experiments using iPSC-derived neurons carrying the P301L tau mutation

Biomed Res Int 1:3548706 Shi M, Wang Y, Yang H, Lai C, Yu J, Sun Y (2024) High doses of radiation cause cochlear immunological stress and sensorineural hearing loss
