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pylori affects the content of -KG in gastric epithelial cells, thereby affecting the histone methylation status of gastric epithelial cells The mechanism by which -KG affects cell proliferation and migration remains unexplored

Protocatechuate is then ring-cleaved by either the ortho (3,4-dioxygenase) or meta (4,5-dioxygenase) pathway, generating -carboxy-cis,cis-muconate or its meta-cleavage analogue, which feed through -ketoadipate or pyruvate/oxaloacetate intermediates into the TCA cycle

Absorbance was measured at 550 nm using a microplate spectrophotometer

Variations in metabolic processes, including glucose uptake and metabolism, mitochondrial function, amino acid uptake, and cholesterol and lipid synthesis in macrophages, are correlated with alterations in cytokine production and phagocytic activity (12)

doi: 10.1038/s41575-021-00430-8