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Vijay R, Guthmiller JJ, Sturtz AJ, Surette FA, Rogers KJ, Sompallae RR, et al
9 Importantly, the key enzyme of GSH synthesis, gamma-glutamyl-cysteinyl-synthetase, is already active by the 2nd trimester of pregnancy, suggesting enzymatic immaturity is unlikely to be a primary limiting factor
Treatment of these conditions during pregnancy should be handled with caution
However, there is a lack of direct evidence surrounding how HMCDs and their conjugates move from the tumor vasculature into the tumor cells
