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Methylation of cytosine at DMRs inhibits the process that pertains to the binding of transcription factors to the locations that are considered regulatory towards the relevant genes, verging on silencing or transcriptional inactivation

( 10.1016/j.jclinepi.2010.07.015) [DOI] [PubMed] [Google Scholar] Banihani S, Agarwal A, Sharma R, Bayachou M.2014

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In a double-blind, randomized, controlled clinical trial, LAC was not inferior to amisulpride in relieving symptoms of dysthymic patients, showing an excellent profile of safety and tolerability [61]