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Many of these forms of treatment represent lifestyle changes meaning it is safe to adopt more than one of the following practices to increase the vagal tone index

While magnesium and amitriptyline each improved many of the assessed parameters, the combination of the two was more effective than either alone and significantly improved pain, tender points, depression, anxiety, sleep, and irritability

However, research has also revealed that free radicals function as damaging agents and as critical mediators of intracellular signaling (Chandimali et al., 2025)

[DOI] [PMC free article] [PubMed] [Google Scholar] [31].Paradies G, Ruggiero FM, Dinoi P, Petrosillo G, Quagliariello E

Study eligibility criteria All English randomised controlled trials analysing any non-surgical treatment option for PD in the acute and chronic phase were included