what is melanotic macules macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Oral melanotic macule - Stock
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Treatment of oxLDL with purified PON1 markedly decreases its ability to induce endothelial cell activation and monocyte binding (264)

This also indicates possible receptor desensitization or compensatory mechanisms

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In a study conducted by The IAMS Company, overweight dogs were fed similar diets

It had semi-opaque pigmentation that applied evenly but pulled into my lip lines noticeably
