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For example, CD38 has been implicated as the enzyme responsible for the generation of other second messengers including NAADP via the base-exchange reaction [4450]

But because unexplained hypercobalaminemia has been consistently associated with an elevated risk of subsequent cancer diagnosis in large population studies, its one of those lab results worth following up on rather than hoping it goes away

However, given the limited sample sizes and observational nature of these studies, such associations should be interpreted cautiously and do not establish causal relationships

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