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These processes regulate not only mitochondrial morphology but also their biogenesis, transportation and localization, quality control and degradation, and apoptotic cell death (219)

In addition, it was found that the activity of this enzyme in erythrocytes significantly decreased the risk of stroke [29]

Malik S, Wong ND, Franklin SS, Kamath TV, LItalien GJ, Pio JR, Williams GR

Vitamin A depletion induced by cigarette smoke is associated with an increase in lung cancer-related markers in rats

16 SIRT1 is broadly expressed in metabolically active tissues 17 and regulates lipid metabolism, 18 mitochondrial maintenance, ROS clearance, autophagy, and immune balance by deacetylating key transcriptional regulators, including peroxisome proliferator-activated receptor gamma coactivator 1- (PGC-1), Forkhead Box O (FOXO), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) and p53