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Cartilage and joint repair models: Intraarticular injection of AOD9604 in a collagenase induced rabbit osteoarthritis model showed improved cartilage architecture and regeneration

Store lyophilized powder at 20C in a sealed vial, protected from light

However, prolonged high doses of vitamin B12 can lead to various side effects: Anaphylactic shock: This allergic reaction to vitamin B12 is rare but very dangerous, potentially leading to death

Professor Ngs research contributions to AOD-9604 development include: Synthesis and characterization of the modified C-terminal growth hormone fragment with enhanced stability Design of the tyrosine N-terminal modification to improve peptide stability and half-life Preclinical studies demonstrating lipolytic effects in obese animal models Advancement of the peptide through multiple phases of clinical development Investigation of mechanisms underlying beta-3-adrenergic receptor modulation His work established the foundation for understanding peptide-based approaches to metabolic regulation, though clinical translation ultimately proved unsuccessful

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