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ROS dysregulation in cardiovascular diseases ROS dysregulation represents a central node in cardiovascular diseases progression [314], involving endothelial dysfunction [315], cardiomyocyte injury [316], mitochondrial [317] and endoplasmic reticulum stress [318], vascular remodeling [319], and atherosclerosis [320]

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In another study, phosgene-exposed animals (500 ppm for 1 minute) received saline (positive control), a low (50 mg/kg), moderate (100 mg/kg), or high (200 mg/kg) dose of NAC, or were exposed to phosgene and untreated (control) (Ji et al., 2010)