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A modified MISI computed on cubic splines of the measured data, resulting in improved identification of glucose peak and nadir, was compared with the original method yielding an increased correlation (=0.576) with the clamp measurement of peripheral insulin sensitivity as compared to the original method (=0.513)

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in vitro bacterial assay (Ames test), did not produce dominant lethal effects in mice, and did not increase chromosome aberration frequency in an 
