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It can be assumed that in glioblastoma with aggressive features, an increase in cellular carnitine content is necessary to fulfill the high energy demand for cell growth and proliferation

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L-carnitine has been found to increase the likelihood of seizures in those who have had seizures previously

In addition to the aforementioned remodelling of the metabolome in fatigue-associated diseases, including long COVID, acylcarnitines have emerged as important modulators of CNS function [29]: In both mice and humans, different classes of acylcarnitines have been found to be altered in either mouse models of depression or humans with MDD, with associations to symptom severity and also treatment response, as reviewed by Liu et al

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