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Additionally, the nitric oxide radical (NO ) is enzymatically synthesized from the oxidation of arginine to citrulline by nitric oxide synthase (NOS) (Hajam et al., 2022)

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In POTS, endothelial dysfunction often leads to abnormal blood pooling in the lower extremities upon standing

54 High concentrations of lipids are explained by macrophage accumulation

2,3-BPG concentration increases in the RBC during adaptation to high altitude, in chronic obstructive pulmonary disease, and in anemia, promoting the release of O 2 to tissues when the O 2 tension and saturation of hemoglobin is decreased in the lung