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(b) dissolving the acid chloride of step (a) in an anhydrous organic inert solvent such as acetonitrile or methylene chloride and adding the alcohol diluted in the same solvent at a ratio comprised between 1:1 and 1:2 at temperatures comprised between 0C and 30C for 2-10 hours, concentrating the solution and, if needed, purifying the compound by chromatography on silica gel

This will enable clinicians to intervene with the right treatment strategies and prevent the evolution of the condition

doi: 10.1155/2012/960363

In addition, it has been found that cisplatin is a substrate of CT2

Fischer, K.A