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Songisepp E
NAC supports tissue levels of glutathione, a key component of the antioxidant defense system, and is a powerful free radical scavenger
doi: 10.1016/j.biopha.2020.110695
2002), and this cysteine modification can sense electrophilic or oxidative conditions to activate Nrf2 (Holland et al
2.2.2 Key driving factors 2.2.2.1 Iron overaccumulation The core driving factor of ferroptosis is the excessive accumulation of iron, and this process is mainly regulated by iron homeostasis regulators such as transferrin receptor (TFR), ferritin, and ferroportin (FPN) (Zhang et al., 2025c)
