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Cells 11(16):2617 Laval L, Martin R, Natividad J, Chain F, Miquel S, de Maredsous CD et al (2015) Lactobacillus rhamnosus CNCM I-3690 and the commensal bacterium Faecalibacterium prausnitzii A2165 exhibit similar protective effects to induced barrier hyper-permeability in mice

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10.1152/physrev.00030.2021 13 BellettiA.D'Andria UrsoleoJ.PiazzaE.MongardiniE.PaternosterG.GuarracinoF.et al (2025)

Heat Shock Protein (HSP33 is a very potent molecular chaperone, which is itself dependent on disulfide bonds

You are building tissue concentrations and assessing tolerance, not yet achieving therapeutic effects