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Diarrhea and vomiting also occurred at higher rates in treatment groups

Because of its crucial functions, maintaining adequate levels of vitamin B12 is essential for overall health

Most available data are preclinical or derived from non-orthopaedic clinical contexts, and robust human orthopaedic trials were not identified

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Bacteria-derived hydroxocobalamin (OHCbl) and CNCbl are converted in humans to useful coenzyme forms to support metabolic processes such as mitochondrial methyl malonyl coenzyme A mutase conversion of methylmalonic acid (MMA) to succinate to link lipid and carbohydrate metabolism, and activation of methionine synthase, the rate-limiting step in the synthesis of methionine