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This occurs because growth hormones can influence metabolic rate and blood sugar regulation
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This drug resistance can be triggered by the genomic instability that leads to tumor heterogeneity, involved in cancer progression
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As shown in Figure 2, as the rate-limiting step in the synthesis of fatty acids, acetyl-CoA reacts with bicarbonate and ATP to form malonyl-CoA, which is catalyzed by acetyl-CoA carboxylase (ACC/POD-2)
