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Description
Medical relevance of common protein-altering variants in GPCR genes across 337,205 individuals in the UK Biobank

Advances in osteosarcoma
The molecule carries an -aminoisobutyric acid (Aib) substitution at position 2 that blocks DPP-IV cleavage, conferring complete resistance to the proteolytic step that inactivates native incretins within minutes

Ahmed AS, Sheng MH, Wasnik S, Baylink DJ, Lau KW

10.1111/all.12298 82 TamerL.CalikogluM.AtesN
