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Gibbs et al., 2007)

These challenges, combined with the low intrinsic permeability of large hydrophilic peptides and proteins, have limited the translation of buccal peptide formulations beyond preclinical development 230

Moreover, leukocytes from leukemia cases exhibited a reduced propensity to attach to surfaces relative to those from healthy people, suggesting that algal polyphenols regulated the adhesive activities of leukocytes in a dose-reliant methods

In this review, the physiological structure and different cells contributing to this barrier are summarized

VDZ has been reported to bind to CD4 T, CD8 T, B, NK, and granulocytes in the peripheral blood 43,44