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In the eye, abnormal iron metabolism affects the pathological process of multiple ophthalmic diseases [14, 15]

In that study, GSTP1 overexpression was found to attenuate oxidative stress and ER stress as well as prevent rotenone-induced neurotoxicity

Upon activation, these T cells release interferon- (IFN-), which downregulates neuronal expression of ferritin heavy chain (FTH1), resulting in increased intracellular labile iron, thereby enhancing susceptibility to ferroptosis

To further elucidate the mechanism by which the NOX2/ET-1 axis mediates microglia activation, pure primary microglia cultures were first incubated with ET-1 (100 nM) for 20 min and 24 h

10.1016/j.colsurfb.2007.09.009 Coll