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Methods Diabetic neuropathy (DN) was induced by high-fat diet-streptozotocin (HFD-STZ) treatment in male Wistar rats and validated by various behavioral and biochemical parameters including serum biochemistry, oxidative stress, inflammatory cytokines, and neuro-specific markers

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This review summarizes the molecular structure and regulation of the Nrf2/Keap1 pathway, including basal and stress-induced activation, post-translational modifications, and cross-talk with PI3K/Akt, MAPK, and NF-B signaling

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