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Injections are reserved for severe neurological involvement, acute pernicious anemia, or any patient where oral compliance is unreliable

In another study on PD patients and healthy controls based on NM-MRI, there was significant reduction in the lateral, central, and medial appearance of the NM high-intensity signals in the SN in patients with early PD (Wang et al., 2018)

This isnt a hard and fast rule, though, as you will see below

11.25.19 Caitlin Copes said: Do you have any idea if the invigorating night treatment is safe

If I attend an appointment at the GP surgery there are no visible notes of any symptoms I have reported, just a factual IM injection in left arm administered on such and such a date