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Furthermore, B-cell lymphoma-2 (BCL2)-interacting protein 3 (BNIP3) and FUN14 domain containing 1 (FUNDC1) have been reported to activate mitophagy via a PINK1-independent pathway and help to protect against oxidative injury and I/R in the heart (Liu et al., 2012

doi: 10.1074/jbc.270.22.13138 92 PedruzziEHakimJGiroudJPPerianinA

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Wt+R+E mice took significantly less time to transverse the 0.6 cm beam (11.84 s 0.65 SEM, p = 0.03) compared to Wt+R+V at day 42 (15.22 s 1.08 SEM) (Fig

Defective Branched Chain Amino Acid Catabolism Impairs Exercise Capacity and Glucose Homeostasis in the Mouse