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In contrast to the remarkable extension of longevity in female and male mice lacking GH or GH receptors, the impact of reduced IGF-1 signaling on longevity of IGF1R mice and mice treated with an antibody to IGF-1 receptor is modest and seen only in one sex (Table 1)

Cancer Control 14 , 295304 (2007)

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Pasternack R, Bchold C, Jhnig R et al (2020) Novel inhibitor ZED3197 as potential drug candidate in anticoagulation targeting coagulation FXIIIa (F13a)

Hazen, MD, Ph.D., senior author of the study and section head of Preventive Cardiology & Rehabilitation at the Cleveland Clinic