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Chronic Psychological Stress Stress is one of the most powerful and underappreciated triggers of mast cell activation

Preclinical validation of these combination strategies is essential to translate this bioinformatics analysis into clinical applications

[DOI] [PubMed] [Google Scholar] 21.OConnor A

TRIM37 overexpression is associated with chemoresistance in hepatocellular carcinoma via activating the AKT signaling pathway

Beyond pharmacologic replacement, several non-pharmacological interventions can modulate the GH/IGF-1 axis: a) regular physical activity and cardiac rehabilitation increase physiological GH pulsatility and IGF-1 levels, improving skeletal muscle function and exercise capacity, b) nutritional optimization and correction of cachexia support IGF-1 synthesis and may partially reverse GH resistance, c) treatment of IR and obesity (e.g., with SGLT2 inhibitors and GLP-1 RAs) may indirectly normalize GH/IGF-1 dynamics by improving metabolic status, sleep quality and systemic inflammation, thus creating a more favorable hormonal milieu for the failing heart