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Key gaps to address: dose-response in humans, safety/tolerability profiles across populations, interaction effects in stacks, and long-term cardiometabolic outcomes

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You may not get enough B12 in your diet if you are: Vegan Vegetarian Over 50 Living with digestive conditions that affect nutrient absorption, such as IBS, celiac, or Crohns disease Taking certain medications like metformin or proton pump inhibitors (PPIs) What are the symptoms of B12 deficiency

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Hong S, Moreno-Navarrete JM, Wei X, Kikukawa Y, Tzameli I, Prasad D, Lee Y, Asara JM, Fernandez-Real JM, Maratos-Flier E, Pissios P. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med. 2015 Aug;21(8):887-94. doi: 10.1038/nm.3882. Epub 2015 Jul 13. PMID: 26168293; PMCID: PMC4529375