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Published studies indexed by resources such as PubMed, NCBI, and journals focused on orthopaedic and gastrointestinal research have contributed to a growing body of preclinical literature

Several mechanisms have been reported for the increased activity of NRF2 in cancers ( Figure 5 ): (1) somatic mutations in KEAP1 or NRF2 , (2) DNA hypermethylation at the promoter region of KEAP1 , (3) the aberrant accumulation of proteins that disrupt the KEAP1NRF2 interaction, (4) transcriptional up-regulation of NRF2 gene through oncogene-dependent signaling, and (5) the modification of KEAP1 protein through oncometabolites

There are many different types of KDs with varying proportions of macronutrients, which have been well described in recent reviews [3,4]

NFkB activation in Mesenchymal Stromal Cells induced by Leukemia-Stroma interaction plays a central role in stroma-mediated chemo-resistance of leukemic cells
