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Crossbreeding of UCHL-eGFP with prpTDP-43 A315T mouse model of ALS, generated prpTDP-43 A315T -UeGFP mice (diseased) and WT-UeGFP mice (healthy control)

16 Idiosyncratic DILI Idiosyncratic DILI is classified into allergic or metabolic types

The Jarisch-Herxheimer Reaction After Antibiotic Treatment of Spirochetal Infections: A Review of Recent Cases and Our Understanding of Pathogenesis

However, when tumor cells are unable to restore homeostasis under chronic stress, sustained and prolonged activation of mechanisms such as the UPR and ISR leads to apoptosis, a process that could potentially be exploited to inhibit tumor growth [19,20,21]

So far, there are four HDACis have been approved by Food and Drug Administration (FAD) for the treatment of patients with cutaneous T cell lymphoma and peripheral T cell lymphoma [86, 87]