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The main proposed mechanisms for the protective actions of xanthines and caffeine in this context include the antagonism of the adenosine A2A receptor (ADORA2A) and inhibition of monoamine oxidase type B (MAO-B)
HIF-2 has been proposed to alleviate inflammation in certain contexts by reducing intracellular iron overload and limiting ferroptosis

Vitamin E in dermatology, Pubmed

doi: 10.1186/s12944-018-0876-4

Pekoak, A., Filp, U., Poot, A