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This long-distance or systemic movement of the silencing signal unfolds over the course of days [191], typically progressing from photosynthetic sources (such as leaves) to sucrose sinks (including roots and growing points) through a bulk flow process
At higher doses, up to 2000 mg/kg body weight/day for 21 days, no mortality, clinical signs of toxicity, or adverse organ pathology were observed, confirming a wide margin of safety (Rosol et al
doi: 10.3390/pharmaceutics15082119
Rahma OE, Hodi FS
