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Once the FeS cluster is assembled, it is ready to be targeted to the transfer proteins

62,99,100 Together, these reports provide strong evidence that after an APAP overdose, in vivo and in isolated hepatocytes in culture, ferrous iron can be released from lysosomes and then taken up into mitochondria via the MCFU, where it contributes to MPTP opening and cell death (Fig

Disruption at any of these regulatory nodes can result in FoxP3 instability, Treg dysfunction, and the emergence of pathogenic exFoxP3 cells, thereby contributing to autoimmune inflammation, such as uveitis

After the stabilization period, the hearts were subjected to 20 min of total ischemia followed by 40 min reperfusion

Progress in Lipid Research
