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As the mature fibre cells that compose the bulk of the lens lack the necessary cellular organelles required to perform de novo protein synthesis, one preferred approach for the prevention of cataract is the preservation of the redox state in the lens

This synergistic integrationusing AI for rapid stratification, multi-omics for deep phenotyping, and targeted systems for precise treatmentforms the definitive framework for translating our understanding of oxidative stress into meaningful clinical benefit and finally fulfilling the unmet promise of MIRI therapy

JCI Insight 2018;3:e99762