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Although chronic stress and high levels of circulating stress hormones are a clear risk factor for depression ( The Effect of Antidepressants on Mitochondria There has been quite a bit of work done to try to understand the effect of antidepressant drugs on mitochondrial function
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2021;38 doi: 10.1016/j.redox.2020.101744
GSH degradation occurs extracellularly, with -glutamyl transferase cleaving the -bond in GSH, GSSG, and conjugates, releasing Cys, forming -glutamyl amino acids and cysteinylglycine (CG)
