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Description
1995 Mar;23(3):436-49

Key points Mechanisms by which microbes might cause rheumatoid arthritis (RA) or spondyloarthritis (SpA) include molecular mimicry, microbial translocation, dysregulation of mucosal immunity, production of immunomodulatory metabolites and immune cell trafficking

TLRs trigger activation of transcription factors, such as NF-B and other intracellular mediators (e.g., HMGB1) causing excessive production of pro-inflammatory cytokines leading to neuronal toxicity underlying intestinal dysfunction (Stojanovska et al., 2015)

However, in the present review we will restrict our discussion to chelation therapy which is an important concept and tool for modifying metal concentrations in the body

These results indicated that transcription expression changed the accumulation of metabolites in glutathione metabolism
