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Secondly, these Syn variants also engage with chaperone machinery, interfering with central protein quality control and clearance pathways, thereby propagating folding defects

For instance, psoriasis-affected skin is associated with increased Corynebacterium spp

2014;9(11):e113366

Similarly, glutamine supplementation effectively reduced toxin-induced apoptosis in human intestinal epithelial T84 cells [88], and sodium laurate-induced apoptosis in RIE-1 cells [89], collectively suggesting that glutamine is critical to suppressing apoptosis

The increased inflammatory response exacerbates kidney damage in CKD patients, showing how chronic stress contributes to the progression of kidney disease through gut-derived signals (Zhou T