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Mechanisms relevant to psoriasis: Reduces NF-B activity (a key inflammatory pathway in psoriasis) Decreases pro-inflammatory cytokines Promotes collagen synthesis and skin remodeling Activates wound healing gene expression Anti-oxidant properties reduce oxidative stress in lesions Research highlight: GHK-Cu has been shown to reset gene expression patterns associated with aging and inflammation

Excessive melanin production leads to hyperpigmentation, such as melasma and dark spots

doi: 10.1038/s41577-019-0151-6 48 ScharerCDBallyAPRGandhamBBossJM

This muscle originates at the pubic bone and inserts along the femur, placing it under substantial mechanical stress during athletic movements

In vivo studies link the effects of CPZ not only on demyelination and the death of oligodendrocytes, but also to the concurrent activation of microglia and astrocytes, in turn leading to an elevation in cytokine production (Buschmann et al., 2012