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Regarding the glutamate metabolic pathways, they also found some limited evidence of altered expression of the excitatory amino acid transporter-2 (synaptic re-uptake), glutamine synthetase (glial change of glutamate to glutamine), and glutaminase (presynaptic change from glutamine to glutamate prior to vesicular re-packaging)

Single culture cells are a good alternative but similar to the above-described situation it remains unclear how the situation in single cells, cell types or tissues (e.g., epidermis) correlates with the situation in whole leaves or other tissues

In a different study, the Bax/Bcl-2 ratio was higher in mice with colitis-associated cancer

Neurotherapeutics 14(2):321332 Lucio-Eterovic AK, Piao Y, de Groot JF (2009) Mediators of glioblastoma resistance and invasion during antivascular endothelial growth factor therapy

Given its importance for brain health and cognitive function, Methylcobalamin B12 is frequently used as a dietary supplement to help prevent or manage vitamin B12 deficiency
