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Phenomenological features of IVD degeneration and facet joint osteoarthritis have considerable overlap, including the destruction of cartilage and other joint tissues, subchondral bone changes, osteophyte formation and reduced joint space

V., McEver, R

Additionally, it protects the energy producing enzyme Glyceraldehyde 3-phosphate dehydrogenase from attack by nitric oxide.
these side effects are inherent with intravenous infusion of any substance