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People on anticoagulants such as warfarin, those with a recent history of severe or changing headaches, and individuals taking multiple central nervous system medications should consult their clinician before starting L-carnitine and may be advised to avoid it or undertake close monitoring.

Nutritional intervention with vitamins, minerals, amino acids and other nutrients have shown considerable promise for the management of migraine

It was recommended to resume L-arginine supplementation starting one month after the oocyte pick-up (OPU) cycle to promote endometrial thickening by the third day of the menstrual cycle