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When the intestinal barrier is damaged, resulting in congenital immune dysregulation, the adaptive immune system becomes crucial

DNA damaging chemotherapies have been used in clinical cancer chemotherapy for decades, and include drugs that induce covalent crosslinks between DNA bases, drugs that attach alkyl groups to bases, and drugs that cause single-strand breaks or DSBs by targeting topoisomerase (Topo) I or II enzymes 83

Despite numerous clinical studies supporting the link between PPI and bacterial gastroenteritis, most prior research designs are imperfect

Oxidative stress, mitochondrial dysfunction, and genetic polymorphisms of the GCLC gene may contribute to this vulnerability