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In zinc-deficient rats, zinc supplementation increased the number of DCs and mucosal cells producing secretory IgA while reducing the production of proinflammatory cytokines IL-6 and IFN-
Recent studies on a rat model have shown that a high-fat diet significantly increases TSH levels and causes thyroid dysfunction, suggesting that excessive consumption of animal fat induces thyroid dysfunction and may contribute to the pathogenesis of hypothyroidism [145,146]
doi: 10.1080/21655979.2021.1956403 51 ZhangPPanYWuSHeYWangJChenLet al
The inability of 5-cholesten-3-one to serve as substrate for the bacterial ketosteroid isomerase was noted in the original publication (Talalay and Wang, 1955), and the purified mammalian GST A3-3 from different sources also lack detectable activity with this steroid (unpublished work in our laboratory)
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