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[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Costantini D, Marasco V, Mller AP

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Furthermore, GSH stores could be depleted from oxidative stress caused by microglial activation and if an individual cannot readily regenerate GSH, low GSH availability may stimulate microglial activation, leading to a cascade of events that potentiates itself

At the molecular level, reduced NNMT activity shifts cellular methylation patterns, potentially altering epigenetic modifications via changes in SAM/S-adenosylhomocysteine (SAH) ratios

Biomarkers of lysosomal and inflammatory pathology are also starting to be explored in PD as markers of poor outcomes