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Description
Wentworth, C., Alam, M
S., Crawford, S
Melanin-like nanoparticles alleviate ischemia-reperfusion injury in the kidney by scavenging reactive oxygen species and inhibiting ferroptosis
Early exploration of this type of linker was successfully conducted by Genentech/ImmunoGen, such as in the ADC drug trastuzumab emtansine (T-DM1 or Kadcyla) for treating HER2-positive metastatic breast cancer
In addition to structural regulation at the mitochondrial level, cells utilize CMA as a selective mechanism for mitochondrial protein clearance
