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Description
Sirtuins, particularly SIRT1, need NAD+ as a cofactor for protein deacetylation

doi: 10.1016/j.critrevonc.2008.09.012

This direct method can raise B12 levels more quickly

-Amino--carboxymuconate--semialdehyde decarboxylase (ACMSD) inhibitors ACMSD plays a crucial role in the kynurenine pathway, serving as a branching point between NAD + and acetyl-CoA production 234

Unlike other B12 types, methylcobalamin doesnt need conversion to work
