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Previous studies have associated serotonin downregulation with schizophrenia (Shah and Gonzlez-Maeso, 2019), and postmortem analyses of brain tissue from schizophrenia patients revealed significantly elevated methylation levels at the HTR2A promoter region ( MB-COMT and 5-HT2A was partially corrected by antipsychotic treatment, and hypermethylation of 5-HT2A in the prefrontal cortex was correlated with treatment response (Figure 6E)

doi: 10.1152/physrev.00042.2016, [DOI] [PMC free article] [PubMed] [Google Scholar] Vervust W., Safaei S., Witschas K., Leybaert L., Ghysels A

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doi: 10.3390/nu17193146 8 KozhuharovVRIvanovKIvanovaS