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Considering the close relationship between the neuronal survival environment and mitochondrial function and dynamics and the widespread reports of induction of neuronal death, including pyroptosis, apoptosis, and necroptosis, by imbalanced mitochondrial dynamics or mitochondrial dysfunction, it can be speculated that mitochondria may be a key factor in activating the unique PANoptosis pathway in neurons (Fricker et al., 2018)

For the hippocampal model, the primary obstacles are establishing direct causal evidence for its role in pain generation and developing testable biomarkers and interventions based on this framework

There is currently no specific inhibitor of prominin2, so it is impossible to inhibit prominin2 directly

10.1016/s0010-7824(98)00047-x 88 MuttukrishnaS.ChildT.LockwoodG

Al-Sadi R, Engers J, Haque M, King S, Al-Omari D, Ma TY
