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Importantly, GR inhibition in the CHD1-deficient setting can restore enzalutamide sensitivity [39], suggesting that GR upregulation is critically involved in resistance to ARSi

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Results In contrast to the CT group, total cholesterol, alanine aminotransferase, systolic and diastolic BP did not change significantly in the LC group after prolonged fasting

It transfers fatty acids into the compartments of the cells, where they are broken down to produce energy

Before sacrifice deep anesthesia was achieved by intraperitoneal injection of 5 mg/kg xylazine hydrochloride, 100 mg/kg ketamine hydrochloride and 0.1 mg/kg atropine sulfate, based on the individual body weight and animals were killed by exsanguination and immediately dissected