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Description
Intervention studies There are no intervention studies in individuals with vitamin B-12 insufficiency or deficiency that have assessed the effect of folic acid supplementation on serum holoTC concentrations, but 2 studies from the 1950s suggest there is an effect

Antagonism of the Prostaglandin D2 Receptor 1 Suppresses Nicotinic Acid-Induced Vasodilation in Mice and Humans

Possible Side Effects Mild injection-site reactions (redness, itching) with subcutaneous administration

Metabolite set enrichment analyses were performed with the platform MetaboAnalyst ( Gene expression analysis Cell lines (5 to 10 10 6 cells) in the exponential growth phase were maintained overnight in fresh culture medium and then had their RNA extracted using the Illustra RNAspin Mini Kit (GE Healthcare Life Sciences, Pittsburgh, PA, USA)

Skin rashes or allergic reactions Most dermatologists recommend doses up to 500 mg daily for up to two months, which are likely safe
